Spring 2001


Annual Fundraising Dinner

by Ted Rudy

The individual alums that are frequently seen here included Karen Ohland, Marcus Hollis, Eric Reindel, Doug Adams, and Erin McGurk with her spouse Ron Dietz. It was great to see Caroline Wang; she lives in the area and took advantage of the proximity and of course, being Secretary of the Board was an added incentive.

Karen Ohland and Caroline Wang were the Masters of Ceremony and began the 'formal' portion of the evening by having an individual introduce everyone seated at their table. This has become a

Standing l-r: Dr. Ken Fischer, Caroline Wang, Karen Ohland, Dr. Jennifer Wayne Seated l-r: Ron Dietz, Erin McGurk, Dr. Savio Woo, Pattie Woo
(continued on Page 11)

In association with the 2001 ORS meeting, our fundraising dinner returned to the R&G lounge in (Chinatown) San Francisco. Our web of contacts continues to grow. We had many new faces: Eiichi Tsuda (Pitt) brought Teruo Kono, a Japanese guest. There were contingents from our various sister labs. Jeff Weiss brought Carlos Bonifasi-Liston and Will Newman from Utah. Thay Lee brought a group from San Diego, Michelle Holmes, Kristen Lemly, Lorraine Panganiban, Chris Powers, Sam Ward, and Bruce Yang. Jennifer Wayne brought along her students Bill Jiranek and John Owen as well as new faculty Matt Bekcman. Bill McGarry has links with both VCU and UC Irvine. There were thirty-five people with Pitt connections. Those that have left the MSRC and returned including Ken Fischer (now at Kansas), Christos Papageorgiou (Greece) and Sven Scheffler (Germany/Harvard), Akihiro Kanamori, Yoshi Takeda, Masayoshi Yagi and Masataka Sakane - all former MSRC fellows from Japan were also able to attend.

page 1

New Board Members

ORLAC would like to announce and welcome its new board members. Doug Boardman, MD is an Orthopaedic Surgeon that did his residency at the University of Pittsburgh. While there, he spent a research year at the MSRC. Doug is currently an Assistant Professor in Orthopaedic Surgery at The Medical College of Virginia in Richmond, VA. Sven Scheffler, MD, was able to spend a year at the MSRC while he was a medical student. Sven has since finished medical school and will begin his internship in the Department of Traumatology and Reconstructive Surgery of the Charite, Campus Virchow Klinikum, Humboldt University of Berlin

(continued on Page 11)

Inside this Issue:

ORLAC Summer Grants Recipients - pg 2

2001 Research Grants Application - pg 3

News From Around the World - pg 4

Dr. Woo's 60th Birthday Celebration - pg 18



ORLAC Newsletter Spring 2001


ORLAC Summer Grant Recipients

Compiled by Serena Chan Saw

The Erin McGurk Grant for female graduate students was awarded to Ms. Ephrat Most. Ms. Most recently completed her Masters degree in Mechanical Engineering at the Massachusetts Institute of Technology and is currently a PhD candidate under the direction of Dr. Guoan Li in the Orthopaedic Biomechanics Lab at the Beth Israel Deaconess Medical Center. Ms. Most spent the summer working on her project entitled "Development of a 6-DOF Robotic Test System for Studying the Biomechanics of Total Knee Replacement".

The first awardee of the Unnamed Clinicians Research grant was Markus Tingart, MD a post-doctoral fellow working with Dr. Maria Apreleva in the Orthopaedic Biomechanics Laboratory at the Beth Israel Deaconess Medical Center. Dr. Tingart's project was entitled "Bone Mineral Density and Trabecular Microarchitecture of the Proximal Humerus and their Relevance to Rotator Cuff Repair".

Sonja Koneczny

It was a great honor for me to receive the Mr.

Sonja Koneczny, the 2000 Recipient of the Mr. & Mrs. Kwock-Chong Woo Summer Research Grant

We are happy to include the following reports from this year's ORLAC Summer Grant Recipients. The full, unedited versions of the reports will soon be available on our website. Ms. Sonja Koneczny was the 2000 winner of the Mr. & Mrs. Kwok-Chong Woo Grant, which is for an undergraduate student. A student at the University of Applied Sciences of Ulm in Germany, Ms. Koneczny spent her summer working with Dr. Doug Adams at the Orthopaedic Biomechanics Laboratory at the University of Connecticut Health Center. The title of her proposal was "Optimization of Tibial Side Free Tendon Fixation using PLLA Interference Screw Techniques".

Mr. Joseph Myers was awarded the Mrs. Ho-Tung Cheong Grant, which is designated for a graduate student. He is a certified Athletic Trainer and is currently pursuing his Ph.D. in Sports Medicine in the School of Education at the University of Pittsburgh. Mr. Myers' proposal was titled "Quantifying the Role of Static and Dynamic Stability in Resistance to a Shoulder Apprehension Force". The work was performed in the Neuromuscular Research Laboratory at the University of Pittsburgh under the direction of Dr. Scott Lephart.

page 2

(continued on Page 11)

Newsletter Publisher

Serena Chan Saw, MS

Board of Directors

President, Richard Debski, PhD

Secretary, Caroline Wang, MS

Treasurer, Jamie Pfaeffle, MD, PhD

Doug Boardman, MD Thay Lee, PhD

Patrick McMahon, MD Karen Ohland, MS Christos Papageorgiou, MD Masataka Sakane, MD

Sven Scheffler, MD Jennifer Wayne, PhD

To reach us:

ORLAC

P.O. Box 7511

Pittsburgh, PA 15213

phone: 412-648-1943

fax: 412-648-2001

email: info@orlac.org

web site: http://www.orlac.org



ORLAC Newsletter Spring 2001


STUDENTS, RESIDENTS, FELLOWS!!!

2001 ORLAC

Summer Research

Grants Program

This year, we are able to offer four opportunities for graduate, undergraduate and medical students, residents or fellows, from the United States and abroad, that you won't want to miss! ORLAC continues its Annual Summer Research Grants Program for 2001 to foster young investigators pursuing musculoskeletal research. What a great way to recognize creative endeavors of the very important members of orthopaedic laboratories!

An application consists of the following:

1) Name of specific award, your address, and other contact information

2) A one page description of the objectives including a description of the project

3) Transcript (applicant must be student during award period) - if applicable

4) Resumé or CV

5) Letter of recommendation from a faculty or industry member

6) Budget for the designated amount

7) Mail all application materials to:

ORLAC

Summer Research Grants Program

P.O. Box 7511

Pittsburgh, PA 15213

The application deadline for the awards is June 20, 2000.

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The Mr. & Mrs. Kwok-Chong Woo Grant

Designated for an undergraduate student to perform musculoskeletal research during the summer of 2001. Maximum budget of $3,000.

The Mrs. Ho-Tung Cheong Grant

Designated for a graduate student to perform musculoskeletal research during the summer of 2001. Maximum budget of $3,000.

The Erin McGurk Grant

Designated for a female graduate student to perform musculoskeletal research during the summer of 2001. Maximum budget of $3,000.

The Unnamed Clinicians Research Grant

Designated for a medical student, resident or fellow to perform musculoskeletal research during the summer of 2001. Maximum budget of $3,000. This grant is currently not endowed. We are seeking contributions from clinicians to help endow and name this grant.

The awardees and their mentors will be contacted by phone and mail by July 13. Checks for the designated amount of the specific award will be made out to the laboratory in which the work is to be conducted, with the understanding that the funds are to be used in support of the awardee's research.

That's all there is to it. So, what are you waiting for? - to have a great summer in research!

If you have any questions, please contact Rich Debski at (412) 648-1638 or genesis1@pitt.edu.



ORLAC Newsletter Spring 2001


Compiled by Caroline Wang, Jennifer Wayne, and Serena Chan Saw

News from Around the World

Goo Hyun Baek, M.D. (MSRC: Orthopaedic Research Fellow, 1995-1996) reports that he was just promoted to associate professor and also received tenure in the Department of Orthopaedic Surgery at Seoul National University Hospital.

Doug Boardman, M.D. (MSRC: Orthopaedic Resident, 1993-1994) and his wife, Cecelia, moved from Rochester, MN (Mayo Clinic) to Richmond, VA to accept faculty positions at The Medical College of Virginia. Cecelia's an Assistant Professor in the Division of Gynecologic Oncology, and Doug is an Assistant Professor in Orthopaedic Surgery. They had a little girl, their first child, Ashley Marie, on March 12, 2001.

Greg Carlin, M.S., J.D. (MSRC: MS., Staff, 1993-1997) hopes all is well. He has been working as a patent attorney for Alston & Bird, a law firm based in the South having over 600 attorneys. Greg has specialized in mechanical, biomedical device and Internet patent filing and prosecution services. He got married in September to Amy Vidovich, a long-time friend and USAirways pilot. They have a house in Charlotte now and a dog named Athena.

Bob Hart, M.D. (UCSD) reports that he is doing well in his third year as Assistant Professor in Orthopaedic Surgery, Chief of Spine Surgery at OHSU in Portland, OR. His daughter Anne is

doing very well in school and recently won a state-wide cello scholarship contest. Bob writes that he would be pleased to see any of the alumni when they get out his way.

Christian Jantea, M.D. (MSRC: Orthopaedic Research Fellow, 1993) has had the opportunity to be the scientific chairman, present scientific papers, as well as organize a conference this past year at various meetings including the Congress of the German Society for Orthopaedics and Tramatology DGOT, the International Congress of the Elbow, the German Society for Surgery of the Shoulder and the Elbow DVSE/DGOT and the Interdisciplinary Upper Limb Conference.

Fengyan Jia, M.D. (MSRC: Orthopaedic Research Fellow, 1999-Present) was involved in a project concentrating on using antisense gene therapy to improve ligament healing this past year. They aim to use antisense oligonucleotides to partially block the production of Type III and Type V collagens, thus improving ligament biological and biomechanical properties.

Meena Joshi, M.S. (UCSD: Undergrad, MSRC: M.S., 1992-1994) and her husband Sujay are expecting their second child this August.

Becky Levine, Ph.D. (MSRC: Ph.D., 1992-1996) got engaged last year to Marc Leibowitz and moved from Newton, MA to Summit, NJ. In Massachusetts, she had been working as a Senior Engineer in R&D for Mitek Products, the sports medicine division of Ethicon, J&J. When she moved to NJ, she transferred to a Sr. Engineer position for another Ethicon division, Gynecare, which develops products for minimally invasive gynecological surgery. (Quite a change from knees to the female reproductive system!!) Becky will be getting married June 3 in Pittsburgh (and will be adopting Marc's last name) and then taking a honeymoon in Italy.

Ben Ma, M.D. (MSRC: Orthopaedic Resident, 1997-1998) and his wife Anita welcomed the birth of their daughter Gabrielle on

Duane Morrow and his sons Nathaniel and Benjamin

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ORLAC Newsletter Spring 2001


April 27, 2001. She is their first child.

Deidre MacKenna, Ph.D. (UCSD: Ph.D., 1990) (and Andrew McCulloch) gave birth to a 10 lb 1 oz baby boy (yes, he is big), Jeremy Alexander McCulloch on October 11, 2000. Jeremy is 7 months old now and growing and changing by leaps and bounds. Deidre is still a group leader in Biology at Tanabe Research Laboratories, USA in San Diego. Pictures of Jeremy are available at: (http://members. home.net/mcculloch/)

Takashi Marui, M.D. (MSRC: Orthopaedic Research Fellow, 1993-1996) is thrilled to announce the birth of his first baby on Feb. 25th, a girl named Moe.

Karen May-Newman, Ph.D. (UCSD: M.S., 1988) received a grant last spring from the Whitaker Foundation for a project entitled "Evaluation of Regional Myocardial Perfusion and Mechanics Using 3-D Myocardial Contrast Echocardiography", which uses 3-D ultrasound to study blood flow and motion in the heart. Her lab at San Diego State University is continuing to work on their computational model of the mitral valve and recently began a new project examining the influence of left ventricular assist devices (LVADs) on pressure and flow in the cardiovascular system. She moved with her husband Peter and son Alex (3 years old) to University City last summer in order to make more room for the newest expected member of their family, a baby girl due at the end of June.

Duane Morrow, M.S. (MSRC: Undergrad, 1992-1995) continues working as an engineer at the Motion Analysis Laboratory (in it's brand new facility) at the Mayo Clinic in Rochester, Minnesota, researching the quantification of

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Standing l-r: Tracy Vogrin, Dr. Teruo Kono, Ephi Most, Dr. Markus Tingert, Dr. Sven Scheffler, Dr. Savio Woo Seated l-r: Dr. Masataka Sakane, Dr. Eiichi Tsuda, Kitty Stabile

cerebellar tremor in MS patients and various types of rehabilitation modelling (wheelchair propulsion and gait modelling for patients receiving various hip implant devices). He has recently been accepted to Iowa State to pursue a Ph.D. in Mechanical Engineering (with a preliminary dissertation subject of hip implant modelling). He and his wife Valerie recently celebrated the first birthday of their sons, Benjamin and Nathaniel.

Ephrat Most, M.S. (MSRC: Undergrad, 1997) is finishing her third year as a graduate student at MIT, the Department of Mechanical Engineering. Her work with Dr. Guoan Li investigates the kinematics of total knee replacement using a robotic testing system.

Nilay Mukherjee, Ph.D. (VCU: M.S. & Ph.D., 1991-1998) finished his post-doctoral fellowship at the Mayo Clinic in Rochester, MN from July 1998 to July 2000, where he was involved in setting up an in vitro system to mechanically load periosteal explants. Since August 2000, he has been an Assistant Professor in Orthopedics and Mechanical and Aerospace Engineering at West Virginia University, teaching one course per semester. He is currently researching a mechanical model of a cell,

(continued on Page 6)


ORLAC Newsletter Spring 2001


News Around the World (cont'd)

measuring intracellular fluid pressure, tissue engineering, and characterizing gene expression in mechanically induced chondrogenesis.

Volker Musahl, M.D. (MSRC: Orthopaedic Research Fellow, 2000-present) is excited about the research he's involved with, comparing repeatability of traditional and robotic ACL-tunnel-placement surgery with the surgical robot CASPAR (computer assisted surgical planning and robotics). He also works on MCL studies, examining the ability of a collagen scaffold (porcine small intestinal submucosa, SIS) to enhance MCL healing. He also briefly worked in the shoulder group on the robotic/UFS testing system, testing human shoulders for instability and force changes before and after creation of a SLAP lesion (detachment of the biceps anchor).

Peter Newton, M.D. (UCSD: Orthopaedic Resident, 1988) continues to focus his clinical practice in the field of scoliosis in San Diego, specifically the thoracoscopic correction of scoliosis. His research this last year focused on clinical outcomes of this type of scoliosis correction with coordination of a prospective multicenter comparison with open anterior and posterior methods. The biomechanics lab where he conducts his research has been productive with projects addressing spinal instrumentation construct stability for a variety of problems. In

addition, the mechanical manipulation of spinal growth in calves remains under investigation as a fusionless method of potentially treating scoliosis in the future. He travelled to Japan, Korea, Taiwan, China, and Singapore for three weeks in April as one of the Scoliosis Research Society Travelling Fellows.

Jamie Pfaeffle, M.D., Ph.D. (MSRC: Ph.D., 1993-1998) is currently an orthopaedic intern at U. Pittsburgh (busy!). He looks forward to starting a year in the MSRC July 1st. He became engaged to his long time girlfriend, Tara.

Ted Rudy, M.A. (MSRC: Staff, 1992-present) is planning his retirement, effective the end of June, 2001. He and his wife Ellen plan to move to central Ohio to be close to their children, to travel, do home projects with their sons and enjoy their 8 grandkids.

Tom Runco, M.S. (MSRC: M.S., 1994-1996) is living in the Philadelphia area and working as an engineer for Synthes Spine. He designs implant systems for the treatment of pediatric and adolescent scoliosis, in addition to degeneration and some fracture. He travels a lot for work to attend various meetings (Whistler, Australia, Cancun) and surgeries (Montreal, Salt Lake, Miami, etc.). Most recently, he spent 2 weeks working in Switzerland with Stratec Medical, Synthes' sister company within the AO foundation. These trips are fun, but mostly he does engineering design work in the office and goes to see an occasional surgery whenever necessary. It is very busy, but never boring. He must say that his time in Pittsburgh's MSRC was a beneficial experience for his current position.

Sven Scheffler, M.D. (MSRC: Medical Student Fellow, 1997-1998) after returning to Germany from the US in Fall 1999, completed his last year of Medical School in Berlin, Germany and graduated December 2000. He is currently in Boston, MA, where he became engaged to his girlfriend, Maria Apreleva, who earned her Ph.D. with the

Standing l-r: Carlos Bonifasi-Liston, Will Newman, Dr. Rich Debski, Dr. Chris Harner, Dr. Savio Woo, Dr. Jeff Weiss Seated l-r: Dr. Pat McMahon, Vitty McMahon, Dr. Jim Kang

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ORLAC Newsletter Spring 2001


MSRC. He returns to Germany in June to start his internship at the Department of Traumatology and Reconstructive Surgery of the Charite, Campus Virchow Klinikum, Humboldt University of Berlin to continue research in the field of knee biomechanics. He will also be trained in the field of traumatology with the special focus on Sports Medicine.

Takatoshi Shimomura, M.D. (MSRC: Orthopaedic Research Fellow, 2000-present) is the fourth research fellow in the MSRC to come from the Department of Orthopaedic Surgery, Kobe University, Japan. Last December, he and his wife, Kazumi, had their first baby, Reika. The "girls" are back in Japan. His research focuses on the healing MCL, specifically SIS (biological scaffold) and antisense gene therapy (to block collagen type III/V synthesis), as approaches to improve collagen alignment and mechanical properties in the healing tissue.

Brooke Spencer (MSRC: Staff, 2000-present) became Dr. Woo's Executive Secretary in September, 2000 and just celebrated her 7-month anniversary on April 5, 2001. She is also taking classes full time to receive an Associate Degree in Business Administration and anticipates her graduation by Spring 2002, after which she will begin baccalaureate work.

Katheryne Stabile, B.S. (MSRC: MS Student, 1999-present) has nearly completed her experimental work involving IOL bi-directional tensile testing and is nearly finished with the FEA of the forearm with IOL bi-directional properties. She plans on defending her thesis this summer. After graduation, she will continue in the lab a bit longer to work on PCL studies part time as well as continue upper extremity work. Unfortunately, she finally broke the trend of research group-related injuries at the MSRC when she tore her ACL and had to have it reconstructed by Pittsburgh's own Christopher Harner, M.D. Since then she has successfully recovered and returned to sports. Over winter break she went to Kauai, Hawaii for a

page 7

Standing l-r: Lou DeCenzo, Dr. Todd Doehring, Diann DeCenzo, Dr. Christos Papageorgio, Dr. Fengyan Jia, Dr. Takatoshi Shimomura, Dr. Lars Gilbertson. Seated l-r: Dr. James Wang, Dr. Savio Woo, Chris Celechovsky
 

wedding and enjoyed the island immensely, proclaiming, "I am ready to move there!"

Robert Svitek, B.S. (MSRC: Undergrad, 1997-1999) is enrolled in graduate school in the Department of Chemical Engineering at the University of Pittsburgh and is doing research on artificial lung devices. He is involved in a project to improve oxygen transfer efficiency in an intravenous membrane oxygenator. He also works part time for the Artificial Heart Program at Presbyterian University Hospital.

Ali Utkan, M.D. (UC Irvine: Research Fellow) continues in his position as a staff surgeon in Ankara Numune Hospital Second Orthopaedic and Traumatology Clinic (Ankara Turkey).

Andy Van Scyoc, B.S. (MSRC: Staff, 2000-present) spent a week in March with 10 University of Pittsburgh students in Morehead, KY participating in Alternative Spring Break where students spend their spring break doing various types of volunteer work. Their project dealt with building low cost homes for the rural poor of Eastern Kentucky as volunteer additions to professional work crews. Work ranged from laying foundation block to shingling a roof and everything in between. The majority of the week was spent with a framing crew starting with a bare foundation and ending with a complete floor and four standing walls. The group was fantastic and a lot fun.

(continued on Page 8)


ORLAC Newsletter Spring 2001


News Around the World (cont'd)

Spirits were extremely high all week even when there was 6 inches of snow and bitter cold. He hopes to attend more of these projects in the future.

Tracy Vogrin, M.S. (MSRC: Undergrad, M.S., Staff, 1995-1999) is finishing up her second year of medical school at the University of Pittsburgh. She still works part time with the PCL Group at the MSRC as well as with the Neuromuscular Research Lab at the University.

Caroline Wang, M.S. (UCSD: M.S., 1987-1989) continues as a stay-at-home mom, enjoying her 4.5 and 2.5 year old children. She and her family moved to Menlo Park, California last summer and are loving the beautiful weather and close proximity to Caroline's two sisters.

Jennifer Wayne, Ph.D. (UCSD: Ph.D., 1985-1990) continues as Associate Professor of Biomedical Engineering at Virginia Commonwealth University. She also acts as the Director of the Orthopaedic Research Laboratory. A new coup for her laboratory was the addition July 2000 of a full-time molecular biologist, Matthew Beckman Ph.D., whose research focus has been in bone metabolism but is expanding to include articular cartilage! Three new graduate engineering students joined her lab this fall: Corrie Spoon, Kelly Shields, and Peter Liacouras. John Owen continues as the laboratory manager and biomechanical engineer extraordinaire. Jennifer's husband, Gene, continues to travel for his job, though mostly domestic. Her daughters, Nancy (6 y.o.) and Stephanie (9 y.o.) are true treasures.

Currently at the Musculoskeletal Research Center, Department of Orthopaedic Surgery at the University of Pittsburgh:

Dr. Savio Woo returned from his sabbatical leave this past June. While at Stanford, he learned more about functional assessment of body motion from Drs. Thomas Andriacchi, Scott Delp, Gene

page 8

Standing l-r: Akane Watanabe, Dr. Yasuhiko Watanabe, Dr. Yoshi Takeda, Dr. Savio Woo, Dr. Yukihisa Fukuda Seated l-r: Dr. Volker Musahl, John Owen,Dr. Matt Beckman, Bill Jiranek

Alexander and their colleagues as well as participated in special bioengineering courses such as bioengineering and industry related projects on research and development as well as tissue engineering. While at Stanford, he was visited by two of the MSRC research fellows, Drs. Masayoshi Yagi and Yukihisa Fukuda. After touring the campus, they enjoyed the seafood at Fisherman's Wharf. Two of his students, Jennifer Zeminski, B.S., and Jorge Gil, B.S., came out for one week to learn how to obtain in vivo kinematics using the point cluster technique. Together with the team from Stanford, they were able to record data on in vivo kinematics. They plan to replay these kinematics on their own robot at the MSRC. Dr. Woo continues to collaborate with Dr. Andriacchi's laboratory at Stanford. Also, much efforts have been devoted to the understanding of small biotechnology firms as well as dot com companies. Hopefully, the MSRC can collaborate and derive funding from some of these companies as well as engage in the entrepreneur spirits of start-ups.

In June of 2000, Dr. Woo received the Distinguished Alumni Award from the College of Engineering, Computer Science, and technology, California State University, Chico. Dr. Woo



ORLAC Newsletter Spring 2001


graduated from Chico State College in 1965 with a B.S. in Mechanical Engineering.

Dr. Woo recently received the Carnegie Visiting Professorship sponsored by the University Court of the Universities of Scotland. He plans to spend one month working with Professor Malcolm Pope at the University of Aberdeen as well as tour six other universities in Scotland. In addition, this professorship provides resources in the amount of $60,000 to allow some of his students and research fellows to join him in collaboration work with these universities as well with Dr. Pope.

Dr. Woo was also recently appointed by Prince Alexandre de Merode, Chairman of the Medical Commission of the International Olympic Committee (IOC) to be the General Secretary for the prestigious IOC Olympic Academy on Sport Sciences. His role in the Academy for the next four years will be to provide leadership on scientific committees, establish procedures to elect memberships as well as to form liaisons with IOC committees and other extramural programs.

The MSRC was very happy to welcome Dr. Jennifer Wayne and Dr. Jeff Weiss, both ORLAC members as MSRC Visiting Professors. Both Jennifer and Jeff were able to come and visit the lab and give a lecture at the MSRC's weekly seminar series. Jennifer spoke on the interdisciplinary approaches to characterizing articular cartilage performance while Jeff discussed his studies of ligament mechanics and healing.

The MSRC sponsored a second symposium this year at the Orthopaedic Research Society Meeting. Steve Abramowitch, B.S., Dr. Eiichi Tsuda and Dr. Woo organized the International Symposium on Ligaments and Tendons held one day before the ORS at Stanford University in California. The goal of this symposium is to bring together researchers with diverse backgrounds to present and discuss new developments in the study of ligaments and tendons. There were four sessions devoted to ligament and tendon biomechanics, biology, tissue engineering and treatments of injury. A special symposium was held to discuss tissue engineering. This special symposium outlined new approaches to engineer tissues

page 9

through the use of growth factors, cell and gene therapy, and mechanical stimuli. Finally, a focus of this symposium was on the future direction of ligament and tendon research. With 120 attendees, this meeting was unique in that there was extra time allotted for discussion to allow students and faculty to receive extensive quality feedback on their research. ORLAC was able to help sponsor the symposium.

The MSRC has also been successful in gaining extramural funding. Grants were funded from a variety of sources. The MCL group was successful in obtaining funding as the Arthritis Foundation has awarded a $225,000 grant for their work entitled: "Inflammatory reaction and apoptosis of tendon fibroblasts are responsible for tendonitis". This grant will cover three years of Dr. James Wang's research. The Shoulder group was awarded two new grants this year from sources including a $100,000 grant from The Aircast foundation, and a $240,000 grant from The Whitaker Foundation. The Aircast Foundation grant will cover two years of research for Dr. Richard Debski on the analysis of reconstruction procedures for acromioclavicular joint injuries while the Whitaker Foundation will cover three years of research on the function of the Capsuloligamentous structures at the Glenohumeral joint during a simulated clinical exam. The Spine group under the direction of Dr. Lars Gilbertson has been awarded a National Institutes of Health grant for $750,000 and a Whitaker Foundation transitional grant for $80,000 to develop a robotics-based spine testing system.

In November of 2000, graduate student Jennifer Zeminski, B.S., won first place in the Masters Level Student Paper Competition of the American Society of Mechanical Engineers at the meeting in Orlando, Florida for her paper entitled "Biomechanical Evaluation of Anterior Cruciate Ligament Reconstruction in Response to External Loads".

This past summer, the MSRC continued to be energized by a number of enthusiastic undergraduate students who spent thirteen weeks

(continued on Page 10)


ORLAC Newsletter Spring 2001


News Around the World (cont'd)

at the MSRC. In the Summer Undergraduate Research Program coordinated by Dr. Lars Gilbertson, the students are assigned to one of the research groups and work closely with their team members throughout the summer. The program culminates with a symposium at the end of the summer where each student presents the successes and challenges they faced as they worked on their project throughout the summer. The presentations were judged by the faculty and staff of the MSRC. The winners were Stephanie Coquia and Kristina Goodoff, both University of Pittsburgh undergraduate students, and were each given an award to commemorate their achievements. Returning student John Jolly of the University of Pittsburgh joined students Fiona Bullen, Stephanie Coquia, Kristina Goodoff, and Maribeth Thomas from the University of Pittsburgh, Maura George from Princeton University and David Lung from Carnegie Mellon University as participants in the program this year.

During this past year, Todd Doehring, Ph.D. defended his doctoral thesis entitled: "Delineation of in-vitro lumbar spine structural properties using a Robotic/UFS testing system with hybrid control: experiments and analytical simulation". Todd has contributed to many projects during his studies here at the MSRC and is continuing his academic work at the University. Eric Wong, M.S. defended his Masters thesis this past November on an "Experimental and computational approach to determine the in situ forces in the bundles of the anterior cruciate ligament". Eric has recently been employed by the University of California at Berkeley and will continue his research there.

During this past year the MSRC welcomed several new faces. Andreas Burkart, M.D. from Technische University of Munich joined us last February for one year as a post-doctoral research fellow working with the ACL and Shoulder groups. Volker Musahl, M.D. has joined us from the Martin Luther Hospital of Humboldt University in Berlin, Germany and is working with both the ACL and MCL groups. Yasuhiko Watanabe, M.D. joined us from Tsukuba University of Japan

page 10

and is working with the ACL group. Takatoshi Shimomura, M.D. has come from Kobe University of Japan and is performing research with the MCL group. Bob Giffin, M.D. has joined us from the University of Western Ontario, London, Ontario and after spending one year on a clinical rotation, works with the PCL group. Rajesh Jari, M.D. from the University of Nottingham of England joined us this past January and is working with both the ACL and Shoulder groups. Finally, Yuhua Song, Ph.D. has joined us this past February from Tsinghua University of Beijing, China and is working with both the ACL and Robotics groups.

Many students have joined us as well this past year. Susan Moore, B.S. from the University of Kentucky has begun her Master's research under the direction of Dr. Richard Debski and the Shoulder Group. Thomas Gilbert, B.S. has joined us from Carnegie Mellon University and has begun his studies under the direction of Dr. Woo and Dr. James Wang and the MCL Group. Brian Campbell, B.S. from the University of Pittsburgh is also studying under Dr. Woo and Dr. Wang. Jing Lei, M.E. obtained her Master's degree in Biochemical Engineering from the Dalian University of Technology in China and has started her graduate studies. Shon Darcy, B.S. has joined us from Walla Walla College in Washington and began his research under Dr. Woo with the ACL and Robotics groups.

Andy Van Scyoc, B.S. recently graduated from the University of Pittsburgh and joined us in July as a staff research engineer. He is working with the ACL group and Dr. Woo on various projects. Mr. Guo-Guang Yang joined the MSRC in January from China with a Masters degree in Mechanical Engineering. He came to the University of Pittsburgh about a year ago and has since been working on cell biology-oriented projects. He is currently working on biological responses of human tendon fibroblasts to repetitive mechanical stretching.

The MSRC welcomed back several undergraduate students. Ryan Costic, John Jolly, and Maribeth Thomas are all undergraduate



ORLAC Newsletter Spring 2001


students from the University of Pittsburgh and, under the direction of Dr. Rich Debski, will complete projects throughout this year. Ryan will enroll as a graduate student this fall and work with Dr. Debski.

John Loh, M.D., a first-year resident, has been spending a year doing musculoskeletal research. John completed his degree at Washington University and is working on projects with the ACL and Robotics groups. John will return to clinical duties in July.

The MSRC also bid farewell to Dr. Ken Fischer who has left the University of Pittsburgh to pursue a new career as faculty at the University of Kansas. Danyel Tarinelli, M.S. a staff engineer, moved back to Boston to begin a new job in industry and pursue her Ph.D.

We are trying to update our database and would like to list how each of you became affiliated with ORLAC. In addition, if you have an address change or exciting news that you would like to share with ORLAC, please let Serena know by: Phone: (412) 648-2023, fax: (412) 648-2001 or email: chanss@pitt.edu. We'd love to hear from you!

Fundraising Dinner (cont'd)

tradition and everyone hid their heads to avoid being put on the spot but it does lead to the casual sense of fun and camaraderie. We had several awardees give testimonials of their experiences with the ORLAC summer grants. In addition to mentors talking about their grantees, two recipients spoke, Ephie Most and Markus Tingert (both from Harvard). Ted Rudy then summarized the aims of the organization and talked about the status of our capital funds and their uses.

Meeting like this year after year has led to a continued acquaintance with former strangers - whether or not one worked directly with them, has met them at previous ORLAC dinners or just recognizes them from the literature. It changes the way one listens to the presentations at ORS (and the pre-ORS International Symposium on Ligaments and Tendons which was sponsored, in part, by ORLAC). Be sure to put us in your plans next year.

Summer Awardees (cont'd)

& Mrs. Kwok-Chong Woo Summer Research Grant from ORLAC for 2000. This grant enabled me to come back to the University of Connecticut Health Center where I already had completed an internship from September 1999 to March 2000. I am a student in Medical Engineering at the University of Applied Sciences in Ulm, Germany. Our program is comparable to the American undergraduate program in Biomedical Engineering. After four years and writing a final thesis I will receive my diploma in August of 2001. This degree is considered between the B.S. and the M.S.

During my internship I had the chance to work with Dr. Douglas Adams and Dr. John Fulkerson on a study of graft fixation in anterior cruciate ligament (ACL) repair. Our study showed that when augmented with an additional bone disc anchor, free tendon fixation with bioabsorbable

Board Members (cont'd)

in June. Masataka Sakane, MD was an Orthopaedic Research Fellow that spent two years at the MSRC. Since returning to Japan, Masa is now an Assistant Professor in the Department of Orthopaedics at Ibaraki Prefectual University of Health Science. Christos Papageorgiou, MD also spent two years as an Orthopaedic Research Fellow at the MSRC. He is now back in Greece at the University of Ioannina. The new board members will be replacing Ted Rudy, MS, who is retiring, as well as Shinro Takai, MD, Glen Livesay, PhD, and Serena Chan Saw, MS. Each outgoing board member served 5 years. Although Serena will no longer be on the board, she will still continue as Newsletter Publisher and maintain the ORLAC database. We would like to thank our past board members for their enthusiastic time of service and welcome our new members.

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ORLAC Newsletter Spring 2001


Summer Awardees (cont'd)

with a 10 x 35 mm screw augmented with a button provides better results than other strategies. However, most of the fixation strategies met the requirements for adequate graft fixation clinically. This leads to the conclusion that free tendon fixation using a suitable interference screw may be a good alternative to the 'gold standard' of bone-patellar tendon-bone fixation. Compared to the promising results of our earlier study using 9 x 23 mm screws augmented with a cortical bone disc, this study demonstrated a further improvement in fixation. Maximum load in the '10 x 35 mm screw plus button' group was always higher than for the '9 x 23 mm plus bone disc' group from the previous study, and similar to that for bone-tendon-bone fixation. The present study also showed that the '9 x 28 mm without augmentation' group provided fixation similar to the '9 x 23 mm plus bone disc' group, while the '9 x 28 mm plus button' group demonstrated yet higher maximum loads. Collectively, these results suggest that a substantial minimum screw length is an important parameter in addition to screw diameter and augmentation.

I want to thank ORLAC for their financial support, making this summer a valuable and unique experience. Thanks to Dr. Adams for being the best supervisor and supporting my work in any possible way. Thanks also to Dr. Patrick Kwok and Dr. John Fulkerson for sharing this project and helping to prepare so many specimens. I am very grateful for the opportunity I had and encourage other students to take advantage of the tremendous opportunities afforded by the ORLAC Summer Grants Program.

Joseph Myers, M.S.

It was a great honor to receive the Mrs. Ho-Tung Cheong research grant. I am grateful to ORLAC for their support. This grant enabled me to purchase necessary equipment as well as provide honorarium moneys to subjects who participated in both preliminary pilot testing and data collection for my dissertation. Under the direction of Scott M. Lephart, PhD, two projects were completed including "In-vivo Neuromuscular Stability Characteristics in a Position of Shoulder

Doug Adams, PhD and Sonja Koneczny intensely study a model of a skeleton in the lab

interference screws is a good alternative to 'gold standard' bone-tendon-bone fixation. The goal of this summer's project was to optimize tibial side free tendon fixation by testing different PLLA interference screw techniques.

The underlying clinical problem driving such studies is that a torn ACL generally does not heal. If the stability of the knee is reduced by a torn ACL, the ACL may be surgically reconstructed with a portion of another tendon from around the knee. The most common surgical repair technique is to use bone-patellar tendon-bone autografts. Advantages of the patellar tendon graft include early bone to bone healing within six to eight weeks and consistent size and shape of the graft. However, harvest site morbidity, anterior knee pain, potential patella fracture and diminished range of knee motion are disadvantages associated with patellar tendon grafts. All of these problems are reasons why using hamstring or quadriceps tendon grafts becomes more advantageous. Our main objective was to determine the best available soft tissue fixation technique which minimized fixation slip and maximized strength.

Evaluation of the data showed that fixation

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ORLAC Newsletter Spring 2001


in augmenting joint stability.

I would like to acknowledge the assistance of several individuals who made these projects possible including, Scott Lephart, PhD, ATC, Patrick J. McMahon, MD, Mark W. Rodosky, MD, Freddie Fu, MD, Yan-Ying Ju, MS, PT, ATC, and Ji-Hye Hwang, MD, PhD. Their help was greatly appreciated. Finally, I am grateful for the assistance the entire Neuromuscular Research Laboratory staff provided during data collection.

Ephrat Most, M.S.

My name is Ephrat Most and I am a Ph.D. candidate in the Department of Mechanical Engineering at MIT. From the bottom of my heart, I would like to thank ORLAC for awarding me the Erin McGurk research award. This provided me with a great opportunity to be involved with musculoskeletal research during the summer of 2000. Because of this fund, I was able to buy equipment necessary for me to carry out my research in the lab, and was able to progress further towards my goal of one day becoming a professor at a research university. I would like to thank Erin McGurk and the board of directors of ORLAC for this wonderful opportunity. I would also like to give special thanks to Lou DeFrate and Andy Silver for their technical assistance.

Development of a 6-DOF Robotic Test System for Studying the Biomechanics of Total Knee Replacement

Human knee joints are subjected to a wide range of forces during daily activities. These forces can be several times body weight for activities such as climbing stairs or rising up from a chair and can be as high as 10 to 20 times body weight for activities such as jumping or running. It is remarkable that the human joint can undergo millions of cycles under such high forces. However, there are many observations of human joint degeneration that eventually lead to surgical intervention. Joint degeneration is poorly understood, but there is no doubt that these high forces contribute to such a process.

Common symptoms of joint degeneration are

Joseph Myers testing a subject using the shoulder apprehension pertubation device

Apprehension" and "In-vivo Neuromuscular Stability Characteristics in Unstable Shoulders."

Dynamic stability is reported to arise from proprioception and neuromotor control over the skeletal muscles crossing the shoulder joint. While proprioceptive deficits have been demonstrated in shoulders diagnosed with glenohumeral instability, questions remain as to how the neuromotor mechanisms are affected. The purpose of this study was to assess both the intrinsic and extrinsic components of stability as measured with muscle-joint complex stiffness, muscle reflex latency, and electromechanical delay in both unstable and stable shoulders during an apprehension perturbation. Subjects diagnosed with traumatic, recurrent, anterior instability were matched with normal subjects. Faster muscle reflex latencies were present with the latissimus dorsi, supraspinatus, infraspinatus upper subscapularis, and lower subscapularis muscles when comparing latencies between the 0% and 20% and 0% and 50% contraction levels. Decreases in electromechanical delay and increases in muscle-joint complex stiffness manifested as muscle contraction increased from 0% to 20% and 20% to 50% respectively. Results from this study indicated that factors other than muscle reflex latency, electromechanical delay, and muscle-joint complex stiffness may contribute to symptoms of shoulder instability. Additionally, the results of this study demonstrated the importance of muscle contraction

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ORLAC Newsletter Spring 2001


Summer Awardees (cont'd)

plays an important role in the restoration of normal knee function post TKA. Others reported that the PCL might contribute to complications after TKA. PCL retention has been advocated for its effect on keeping the femoral component rolling motion on the tibial plateau, and reducing tibial shear forces. Others demonstrated that the PCL does not always cause posterior roll back of the femur in squatting, which might accelerate polyethylene liner wear on TKA. Further, inadequate PCL tension may cause abnormal kinematics following TKA.

The primary objective of this work was to compare two existing TKA design and compare their kinematics and kinetics with the intact knee. In this study, a newly developed robotic testing system was used to investigate TKA biomechanics. A quasi-Newton control algorithm that accounts for the coupling effect of the different DOF was developed. This robotic system determines the intact knee kinematics, the kinematics of PCL-retaining (PCR) TKA, PCL-deficient TKA, and PCL-substituting (PS) TKA using the same knee. Therefore, intra-specimen variation was minimized.

Nine fresh-frozen human knee specimens were tested using the above robotic testing system. During the experiment, the femur was fixed to a pedestal while the tibia was fixed to the robot through the load cell (Figure 1). This allowed the tibia to freely move in 6-DOF about the femur.

Figure 1: The robotic testing system including specimen installation and muscle load

The native knee was tested first. Its neutral path from full extension to 120° of flexion was

Joseph Myers with research advisor

Scott Lephart, PhD, ATC

reduced joint flexibility, development of bony spurs, joint pain, and swelling of the joint. Osteoarthritis (OA) is one of the major degenerative joint diseases that develop in joints that are injured by repeated overuse in the performance of a particular activity or from carrying excess bodyweight.

Total knee arthroplasty (TKA) has been a popular surgical procedure to treat people with severe degenerative joint disorder such as OA. This surgery is also performed to replace a badly fractured knee. In 1994, there were 230,342 TKA surgeries performed in the United States; 211,872 primary TKAs and 18,470 revisions. Further, in 1997, the number of inpatient procedures for arthroplasty and knee replacement increased to 338,000 [National Center for Health Statistics, National Hospital Discharge Survey, 1997]. TKA implants do not last indefinitely in the joint. The main mechanisms for TKA failure are loosening of the prosthesis from the bone, joint infection, polyethylene wear, component instability, poor range of motion, bone fracture, and patella complications. The joint may need to be changed but the second operation, which is more difficult than the first, may not be as successful and the knee may need to be stiffened.

One of the most controversial issues regarding TKA is the role of the posterior cruciate ligament (PCL). Two schools of thoughts regarding the PCL contribution to TKA outcome can be found in the literature. Some researchers found that the PCL

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ORLAC Newsletter Spring 2001


determined using a Quasi-Newton control algorithm. Once the native knee neutral path was recorded, a posterior cruciate retaining TKA was performed on the same knee (NexGen, Zimmer). All surgery were performed by an orthopedic surgeon. Through a standard midline skin incision, a medial parapatellar arthrotomy was performed. The anterior cruciate ligament was removed. Appropriate instrumentation was used for the bone cuts. Trail components were inserted and ligamentous balancing was performed. Stability and soft tissue tension ware confirmed, the definite components were inserted. The femoral component was inserted in a press fit manner while the tibial component was cemented in. The patella was not resurfaced in these experiments. The arthrotomy and the skin were closed using a continuous suture.

A new neutral path for the PCR TKA knee was determined by the robotic testing system using the same protocol as the native knee. This neutral path reflects the geometric characteristics of the TKA as well as the interaction with the surrounding tissues.

Finally, a PS TKA was performed on the same knee. This was performed by removing the non-cemented femoral component and reinserting the PS TKA. In cases where there was some bone loss leading to instability of the component, the new femoral component was cemented. A matching PS polyethylene with tibial spine was used. Post component modifications, a new neutral path of PS TKA was determined by the robotic testing system using the same protocol. The posterior femoral translation of the native knee and the three TKAs were compared. A repeated measures ANOVA with within factors was used. Statistical significance was set at p<0.05.

The posterior femoral translation of the native knee as well as the TKA knees on the neutral path are shown in Figure 2. In the native knee, the posterior femoral translation (PFT) was observed throughout the whole range of motion (from 0° to 120° of flexion). At 15°, the PFT was measured as 2±2mm. This value increased to 8±3mm at 60°. The maximum PFT was 15±8mm at 120° of

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flexion.

In the PCR TKA, the femur was positioned posteriorly by 1.5±3mm at full extension when compared to femur position for the native knee. At 30°, a 0.5±3mm anterior translation was observed for the femur position. No PFT was detected for flexion angles smaller than 60°. At 60° of flexion, a 2.5±3mm PFT was measured which is significant lower (p<0.05) than of the native knee. Peak value of the PFT was recorded at 120° of flexion (9.5±6mm). This peak value was also found to be significantly lower than that of the native knee at the same flexion angle.

Figure 2: Posterior femoral translation for native knee and TKAs on the neutral path.

When the PCL was dissected from the specimen, the femur showed similar pattern in PFT as in PCR TKA for 0° and 30° of flexion angles. Even though the PFT observed was -2±5mm at 30°, it was not significantly different than that of the PCR TKA. At 60°, the femur in PCL sacrificed knee was still translated anteriorly by 0.9±7mm. The PFT peak was found to be 4±6mm at 120° of flexion. This peak value significantly (p<0.05) lower than both the native knee and the PCR TKA.

The PFT of the PS TKA was similar to that of the PCL sacrificing knee for flexion angles between 0° and 60°. At 60°, the femur translated anteriorly by 1±7mm. At 90°, the femur translated posteriorly by 2.5±7mm, which is significant lower than that of both the native and the PCR knees. Peak value was observed at 120° and was found to be 10.5±6mm. This peak value was found to be

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ORLAC Newsletter Spring 2001


Summer Awardees (cont'd)

rollback, however, was only partially restored after TKA on the neutral path. When comparing PCR and PS TKAs we found that cruciate retaining rollback occurs at a lower flexion angle. However, at deep flexion both TKAs reach the same maximum level. No significant difference between the two TKAs was noted (p>0.05). This study demonstrates the important contribution of the PCL and the cam-spine interaction in restoring femoral rollback after TKA.

Markus Tingart, M.D.

The generous financial support from ORLAC in the form of the "Unnamed Clinicians Research Grant" provided us with the unique opportunity to perform the following project. It allowed us to explore new scientific questions in the field of shoulder biomechanics.

This work would not have been possible without the tremendous support of the whole team at the Orthopedic Biomechanics Laboratory at Beth Israel Deaconess Medical Center in Boston. I would like to thank everyone at the OBL and particularly Dr. JP Warner for his guidance in the project and Maria Apreleva for supervising the project and spending countless hours discussing the study design and the results.

The last ten months have been very busy and productive, and we are glad to present the results of our major project in this final report.

Characterization of the Three - Dimensional Bone Mineral Density Distribution in the Proximal Humerus.

It is known that the incidence of osteoporosis increases with age. In particular, in elderly female patients, osteoporotic changes and reduced bone quality result in a higher risk for fractures of the vertebral bodies, the distal radius, the proximal femur and the proximal humerus. Osteoporosis of the proximal humerus often complicates internal fixation of proximal humeral fractures as well as osseous tendon fixation in rotator cuff (RC) repair.

Despite the high clinical relevance of the bone quality of the proximal humerus, little is known about the bone mineral density (BMD) of the proximal humerus.

Markus Tingert, MD and Ephi Most, MS are hard at work in Boston

similar to that of the PCR TKA. Both PCR and PS TKAs recovered about 65% of the native knee kinematics at full flexion (120°).

Posterior femoral translation occurs in both the native knee and TKAs. However, none of the TKAs fully restored native knee kinematics on the neutral path. The posterior femoral translation of the PCR TKA was approximately 40% lower at 90° and 120° of flexion compared to the native knee. Sacrifice of the PCL in the PCR TKA resulted in little posterior femoral translation for all flexion angles. This finding suggests that the PCL does play an important role in rollback of the TKA on the neutral path. The cam-spine interaction appears to contribute to femoral rollback in PS TKA. Posterior femoral translation and cam-spine contact occur at a similar flexion angle, suggesting that the cam-spine system supplements for the function of PCL.

This study reconfirms the existence of rollback in the native knee and in TKA. Native knee

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ORLAC Newsletter Spring 2001


We analyzed the total BMD of the proximal humerus with Dual Energy X-Ray Absorptiometry (DEXA) and found a significant decrease in total BMD from the proximal to the distal part of the humeral head. The bone quality of the greater and lesser tuberosity is of particular interest for transosseous or suture anchor fixation in rotator cuff repair. We found a significantly lower total BMD for the greater tuberosity compared to the lesser tuberosity.

The two-dimensional DEXA technique cannot distinguish between trabecular and cortical bone. A more detailed knowledge of the cortical and trabecular BMD distribution is important for a better understanding of the biomechanical properties of internal fixation in proximal humeral fractures as well as differences in suture anchor pullout strengths. We performed peripheral Quantitative Computer Tomography (pQCT) to investigate the three-dimensional BMD distribution by differentiating between trabecular and cortical BMD. There is an overall decrease in trabecular and cortical BMD from the proximal to the distal part of the humeral head. Furthermore, there are significant differences in BMD between the anterior and posterior part of the articular surface as well as between the greater and lesser tuberosity. In addition, there are regions of significantly different cortical and trabecular BMD within the area of the greater and lesser tuberosity.

Correlation between BMD of the Proximal Humerus and Suture Anchor Pullout Strength in Rotator Cuff Repair.

The ideal RC repair shows a high initial fixation strength and allows minimal gap formation. In osteoporotic bone, transosseous or suture-anchor tendon to bone fixation remains a weak link of the RC repair. Transosseous sutures may cut through bone and suture anchors may pull out of bone before tendon healing. An overall failure rate of up to 68 percent is reported in the literature. Recent studies did not find a correlation between suture anchor pullout strength and total BMD of the proximal humerus.

Based on our more detailed knowledge of the total, trabecular and cortical BMD of the entire

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humeral head as well as of specific regions of interest (ROI), we hypothesize that there is a correlation between BMD and suture anchor pullout strength and that there are differences in pullout strength depending on the location of anchor placement.

The greater tuberosity was separated into three ROIs, and the entire lesser tuberosity was taken as one ROI. Suture anchors were placed in the area of the anatomical neck medial of the tip of the tuberosities and in the lateral cortex of the tuberosities. Cyclic suture anchor pullout tests were performed.

We found a significant correlation between suture anchor pullout strength and BMD. Furthermore, we found significant differences in anchor pullout strength between the defined ROIs. Suture anchor pullout strengths were significantly higher in the lesser tuberosity than in the greater tuberosity. Anchors placed in the area of the anatomical neck were found to have significantly higher pullout strengths than those inserted in the lateral cortex.

The overall results of this study may help us to better understand the three-dimensional BMD distribution in the proximal humerus and to facilitate the development of surgical techniques to improve the outcomes after proximal humeral fractures and rotator cuff tears.

Markus Tingert, MD the 2000 Unnamed Clinicians Research Grant Awardee


ORLAC Newsletter Spring 2001


Dr. Woo's 60th Birthday Celebration

ORLAC would like to announce that we will be holding a symposium in honor of Dr. Savio Woo's 60th birthday. Dr. Woo will be turning 60 on July 26, 2001. In order to celebrate this joyous occasion and to honor his contributions to the field of biomechanics, we are planning two events on Saturday, July 14, 2001. The festivities will take place on the campus of the University of Pittsburgh and includes a one-day symposium followed by a banquet in the evening.

The symposium on "Bioengineering at the Dawn of the 21st Century" will be held in Scaife Hall, Lecture Room 1 from 8:00 a.m. until 4:30 p.m. The speakers will feature current and former students and fellows of Dr. Woo and address current developments and future directions in orthopaedic research as well as other bioengineering disciplines. A banquet will follow at the nearby Wyndham Garden Hotel with cocktails and dinner.

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If you are planning to join us, a block of rooms has been set aside at the Wyndham Garden Hotel under "Dr. Woo's 60th Birthday Symposium". They are available on the 13th and the 14th of July for $99/night. The Wyndham is located at 3454 Forbes Avenue, Pittsburgh, PA 15213 and their phone number is (412) 683-2040.

In addition, Dr. and Mrs. Woo have graciously invited everyone to their home for a picnic on the evening of Friday, July 13th. More details will follow, but please keep it in mind when planning your travel arrangements.

For further information, please contact:

Ms. Colleen O'Hara

Email: cohar@pitt.edu

Tel: 412-648-2000

Fax: 412-648-2001


ORLAC

P.O. Box 7511

Pittsburgh, PA 15213

FORWARD & ADDRESS CORRECTION REQUESTED